Author: Zhou, Ya-Qun; Liu, Dai-Qiang; Chen, Shu-Ping; Sun, Jia; Zhou, Xue-Rong; Xing, Cui; Ye, Da-Wei; Tian, Yu-Ke
Title: The Role of CXCR3 in Neurological Diseases Document date: 2019_2_23
ID: xago1ts3_4_1
Snippet: was also demonstrated to have a role in recruiting pathogenic T lymphocytes in the brains of patients with Rasmussen encephalitis [54] . Using surgical specimens of children with Rasmussen encephalitis, they found that CXCR3 was expressed in cytotoxic T lymphocytes infiltrating the damaged areas of primary biopsies, whereas CXCL10 was expressed in neurons and astrocytes in the same areas. Additionally, in vitro study demonstrated that astrocytes .....
Document: was also demonstrated to have a role in recruiting pathogenic T lymphocytes in the brains of patients with Rasmussen encephalitis [54] . Using surgical specimens of children with Rasmussen encephalitis, they found that CXCR3 was expressed in cytotoxic T lymphocytes infiltrating the damaged areas of primary biopsies, whereas CXCL10 was expressed in neurons and astrocytes in the same areas. Additionally, in vitro study demonstrated that astrocytes upregulated the mRNA expression level of CXCL10 and the release of CXCL10 to the supernatants in response to infections, which was completely abolished by CXCR3 antagonist. These results suggested that astrocytes and neurons may recruit pathogenic T lymphocytes into areas of the brain of Rasmussen encephalitis through the CXCL10-CXCR3 axis.
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