Selected article for: "p62 signal and translocation phenotype"
Title: The signal sequence of the p62 protein of Semliki Forest virus is involved in initiation but not in completing chain translocation
  • Document date: 1990_9_1
    • ID: rmjv56ia_32
    Snippet: We conclude that the 40 residue peptide from the p62 NH2-terminal region confers a translocation positive phenotype to the p62-globin and p62-dhfr polypeptides and therefore must contain a functional signal sequence. The translocated fusion proteins were also shown to be glycosylated. This must involve Asn~3 of the p62 peptide as it is part of the only potential glycosylation site on the hybrid polypeptides (Garoff et al., 1980 ; references on dh.....
    Document: We conclude that the 40 residue peptide from the p62 NH2-terminal region confers a translocation positive phenotype to the p62-globin and p62-dhfr polypeptides and therefore must contain a functional signal sequence. The translocated fusion proteins were also shown to be glycosylated. This must involve Asn~3 of the p62 peptide as it is part of the only potential glycosylation site on the hybrid polypeptides (Garoff et al., 1980 ; references on dhfr sequence in legend to Fig. 1) , Finally, we can also conclude that the p62 signal sequence does not provide a stable membrane anchor to the translocated chain.

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