Author: Clayton M. Carey; Sarah E. Apple; Zoe A. Hilbert; Michael S. Kay; Nels C. Elde
Title: Conflicts with diarrheal pathogens trigger rapid evolution of an intestinal signaling axis Document date: 2020_3_30
ID: ju826pao_4
Snippet: In addition to primates, STa toxicity has been demonstrated in other mammalian species including rodents and livestock 4 . To test whether GC-C might be subject to recurrent positive selection in other mammalian lineages, we collected sequences of GC-C from four additional groups of mammals including Bovidae (cloven-hooved ruminants), Caniformia (suborder of dog-like carnivores), Myomorpha (mouse-like rodents), and Chiroptera (bats) (Table S1 ). .....
Document: In addition to primates, STa toxicity has been demonstrated in other mammalian species including rodents and livestock 4 . To test whether GC-C might be subject to recurrent positive selection in other mammalian lineages, we collected sequences of GC-C from four additional groups of mammals including Bovidae (cloven-hooved ruminants), Caniformia (suborder of dog-like carnivores), Myomorpha (mouse-like rodents), and Chiroptera (bats) (Table S1 ). In contrast to primates, substitution patterns among Caniformia and Bovidae are consistent with purifying selection, while signals of positive selection are supported in only a subset of tests among Myomorpha GC-C (Table S2) .
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