Therapeutic Efficacy and Safety of Prolonged Macrolide, Corticosteroid, Doxycycline, and Levofloxacin against Macrolide-Unresponsive Mycoplasma pneumoniae Pneumonia in Children

Ha, Seok Gyun; Oh, Kyung Jin; Ko, Kwang-Pil; Sun, Yong Han; Ryoo, Eell; Tchah, Hann; Jeon, In Sang; Kim, Hyo Jeong; Ahn, Jung Min; Cho, Hye-Kyung

The total number of subjects who met the inclusion criteria for MP diagnosis within the study period was 1,165. After exclusion by our study criteria, 190 cases (16.3%) of macrolideunresponsive MP pneumonia were enrolled. Among those, 138 cases were continuously treated with macrolide approximately for 7-14 days, and 32 cases were treated with addon CST and continuous macrolide. Fourteen and 6 cases were treated with secondary antimicrobial therapy with DXC and LFX, respectively. Two patients were excluded: one patient had improved when administered a combination therapy of corticosteroid and LFX after treatment failure of the add-on of corticosteroid alone; the other patient was treated with corticosteroid and LFX simultaneously.