VIGOR extended to annotate genomes for additional 12 different viruses

Wang, Shiliang; Sundaram, Jaideep P.; Stockwell, Timothy B.

Measles virus has a non-segmented, negative-stranded RNA genome, which is 15.8 kb and encodes six genes (N, P, M, F, H and L). In addition to the P protein, the P gene also encodes two other proteins (V and C) through different mechanisms. The C protein translation initiates from an alternative start codon with a different reading frame; the V protein is identical to the P protein at the N-terminal domain, but the C-terminal domain is different because of RNA editing, which results in one G residue insertion at the RNA editing site. In the mumps virus genome, one extra small hydrophobic protein is encoded between the fusion gene and the HN gene. The P gene encodes two proteins (P and V). Two non-templated G residues are inserted into the mature transcript that is going to be translated into the P protein, and the mRNA without editing encodes the V protein (6) .