Author: Collin D. Heer; Daniel J. Sanderson; Yousef M.O. Alhammad; Mark S. Schmidt; Samuel A.J. Trammell; Stanley Perlman; Michael S. Cohen; Anthony R. Fehr; Charles Brenner
Title: Coronavirus Infection and PARP Expression Dysregulate the NAD Metabolome: A Potentially Actionable Component of Innate Immunity Document date: 2020_4_18
ID: 033phqmd_33
Snippet: Based on in vivo expression data, approaches 3 and 4 have strong potential with the caveat that at pharmacological doses, NAM has the potential to function as a PARP inhibitor (Rankin, Jacobson, Benjamin, Moss, & Jacobson, 1989) . In the ferret, NMRK1 and NAMPT expression were both up about 2-fold (NMRK1 achieved statistical significance). In the deceased human lung sample, NAMPT was up about 4-fold while NMRK1 and NMRK2 were up 2-and 4-fold, tho.....
Document: Based on in vivo expression data, approaches 3 and 4 have strong potential with the caveat that at pharmacological doses, NAM has the potential to function as a PARP inhibitor (Rankin, Jacobson, Benjamin, Moss, & Jacobson, 1989) . In the ferret, NMRK1 and NAMPT expression were both up about 2-fold (NMRK1 achieved statistical significance). In the deceased human lung sample, NAMPT was up about 4-fold while NMRK1 and NMRK2 were up 2-and 4-fold, though neither of the NMRK gene expression differences exceeded the significance cut off. The actual efficacy of NR and NAM will need to be assessed in ferret and other animal trials because dose and formulation could affect delivery to the airways.
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