Author: Dawson, Patrick; Malik, Mamunur Rahman; Parvez, Faruque; Morse, Stephen S.
Title: What Have We Learned About Middle East Respiratory Syndrome Coronavirus Emergence in Humans? A Systematic Literature Review Document date: 2019_3_1
ID: yb54i1ne_29
Snippet: Unfortunately, there are pitfalls in serology, including cross-reactivity and false negatives. In 2014, CDC preliminarily reported a MERS-CoV case with a positive ELISA and IFA, but later retracted the case report due to a negative microneutralization result (Breakwell et al. 2015) . Consequently, CDC no longer recommends IFA but instead now recommends using two different ELISA tests, with microneutralization for confirmation (CDC 2014, revised) .....
Document: Unfortunately, there are pitfalls in serology, including cross-reactivity and false negatives. In 2014, CDC preliminarily reported a MERS-CoV case with a positive ELISA and IFA, but later retracted the case report due to a negative microneutralization result (Breakwell et al. 2015) . Consequently, CDC no longer recommends IFA but instead now recommends using two different ELISA tests, with microneutralization for confirmation (CDC 2014, revised) . Conversely, low or waning antibody response after infection, which would yield false negatives, has also been reported . False negatives are further discussed below in the section on Host Response.
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