Selected article for: "active viral infection and acute infection"
Author: Daoud, Ahmed; Alqassieh, Ahmad; Alkhader, Duaa; Posadas Salas, Maria Aurora; Rao, Vinaya; Fülöp, Tibor; Soliman, Karim M.
Title: Immunosuppression in kidney transplant recipients with COVID-19 infection – where do we stand and where are we heading?
  • Cord-id: 8ccxcru5
  • Document date: 2021_1_24
    • ID: 8ccxcru5
    Snippet: The appropriate immunosuppressive regimen in kidney transplant recipients with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2/COVID-19) infection remains unclear. The impact of direct virus injury complicated by dysregulated hyperimmune response with overwhelming release of various cytokines in COVID-19 infected subjects contributes to the complexity of management. The largest concern of the practicing clinicians at current time is how to tailor maintenance immune-modulating therapy
    Document: The appropriate immunosuppressive regimen in kidney transplant recipients with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2/COVID-19) infection remains unclear. The impact of direct virus injury complicated by dysregulated hyperimmune response with overwhelming release of various cytokines in COVID-19 infected subjects contributes to the complexity of management. The largest concern of the practicing clinicians at current time is how to tailor maintenance immune-modulating therapy during active viral infection and the efficacy of the soon-to-be upcoming immunization for COVID-19. This targeted review aims to cover most of the current evidence on the effect of key maintenance immunosuppressive agents in COVID-19 infection and proposes a line of management to specific scenarios on this very rapidly evolving subject.

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