Selected article for: "acute respiratory syndrome and lung histopathology"
Author: Chak-Yiu Lee, Andrew; Zhang, Anna Jinxia; Fuk-Woo Chan, Jasper; Li, Can; Fan, Zhimeng; Liu, Feifei; Chen, Yanxia; Liang, Ronghui; Sridhar, Siddharth; Cai, Jian-Piao; Kwok-Man Poon, Vincent; Chung-Sing Chan, Chris; Kai-Wang To, Kelvin; Yuan, Shuofeng; Zhou, Jie; Chu, Hin; Yuen, Kwok-Yung
Title: Oral SARS-CoV-2 inoculation establishes subclinical respiratory infection with virus shedding in golden Syrian hamsters
  • Cord-id: 8qj41kpp
  • Document date: 2020_9_22
    • ID: 8qj41kpp
    Snippet: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is transmitted largely by respiratory droplets or airborne aerosols. Despite being frequently found in the immediate environment and faeces of patients, evidence supporting oral acquisition of SARS-CoV-2 is unavailable. Utilizing Syrian hamster model, we demonstrate that the severity of pneumonia induced by intranasal inhalation of SARS-CoV-2 increases with virus inoculum. SARS-CoV-2 retains its infectivity in vitro in simulated human
    Document: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is transmitted largely by respiratory droplets or airborne aerosols. Despite being frequently found in the immediate environment and faeces of patients, evidence supporting oral acquisition of SARS-CoV-2 is unavailable. Utilizing Syrian hamster model, we demonstrate that the severity of pneumonia induced by intranasal inhalation of SARS-CoV-2 increases with virus inoculum. SARS-CoV-2 retains its infectivity in vitro in simulated human fed-gastric and fasted-intestinal fluid after two hours. Oral inoculation with the highest intranasal inoculum(105PFU) causes mild pneumonia in 67% (4/6) of the animals with no weight loss. The lung histopathology score and viral load are significantly lower than those infected by the lowest intranasal inoculum(100PFU). However, 83% oral infection (10/12 hamsters) have similar level of detectable viral shedding from oral swabs and faeces as that of intranasally infected hamsters. Our findings indicate oral acquisition of SARS-CoV-2 can establish subclinical respiratory infection with less efficiency.

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