Author: Courtney R. Sullivan; Catharine A. Mielnik; Sinead M. O’Donovan; Adam J. Funk; Eduard Bentea; Erica A.K. DePasquale; Zhexing Wen; Vahram Haroutunian; Pavel Katsel; Amy J. Ramsey; Jarek Meller; Robert E. McCullumsmith
Title: Connectivity analyses of bioenergetic changes in schizophrenia: Identification of novel treatments Document date: 2018_6_5
ID: ltb6l5xz_39
Snippet: In the elevated plus maze, we detected an effect of genotype (p< 0.0001). GluN1 knockdown animals spent significantly more time in the open arms than did WT mice, regardless of pioglitazone/vehicle treatment ( Figure S19 ). Increased time in the open arm indicates a lack of anxiety and is observed in mouse models of mania-like behavior. We did not detect any significant differences in genotype or drug treatment in our social paradigm ( Figure S.....
Document: In the elevated plus maze, we detected an effect of genotype (p< 0.0001). GluN1 knockdown animals spent significantly more time in the open arms than did WT mice, regardless of pioglitazone/vehicle treatment ( Figure S19 ). Increased time in the open arm indicates a lack of anxiety and is observed in mouse models of mania-like behavior. We did not detect any significant differences in genotype or drug treatment in our social paradigm ( Figure S20 ). We did not detect any differences in the acoustic startle response between any groups, although GluN1 knockdown animals tended to have higher startle responses ( Figure 8 The copyright holder for this preprint (which was not peer-reviewed) is the author/funder. It . https://doi.org/10.1101/338392 doi: bioRxiv preprint
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