Selected article for: "dengue virus and Japanese Encephalitis virus"
Author: Liang, Pi‐Hui; Cheng, Wei‐Chieh; Lee, Yi‐Ling; Yu, Han‐Pang; Wu, Ying‐Ta; Lin, Yi‐Ling; Wong, Chi‐Huey
Title: Novel Five‐Membered Iminocyclitol Derivatives as Selective and Potent Glycosidase Inhibitors: New Structures for Antivirals and Osteoarthritis
  • Cord-id: 412qre64
  • Document date: 2006_1_5
    • ID: 412qre64
    Snippet: A novel 5‐membered iminocyclitol derivative was found to be a potent and selective inhibitor of the glycoprotein‐processing α‐glucosidase with a K(i) value of 53 nm. This compound was further derivatized to antiviral agents against Japanese encephalitis virus, dengue virus serotype 2 (DEN‐2), human SARS coronavirus, and human β‐hexosaminidase (K(i) =2.6 nm), a new target for the development of osteoarthritis therapeutics.
    Document: A novel 5‐membered iminocyclitol derivative was found to be a potent and selective inhibitor of the glycoprotein‐processing α‐glucosidase with a K(i) value of 53 nm. This compound was further derivatized to antiviral agents against Japanese encephalitis virus, dengue virus serotype 2 (DEN‐2), human SARS coronavirus, and human β‐hexosaminidase (K(i) =2.6 nm), a new target for the development of osteoarthritis therapeutics.

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