Author: Haley R. Harrington; Matthew H. Zimmer; Laura M. Chamness; Veronica Nash; Wesley D. Penn; Thomas F. Miller; Suchetana Mukhopadhyay; Jonathan P. Schlebach
Title: Cotranslational Folding Stimulates Programmed Ribosomal Frameshifting in the Alphavirus Structural Polyprotein Document date: 2019_10_2
ID: 4ju3x2bf_18
Snippet: Overall, we find the -1PRF efficiency associated with each polyprotein variant roughly scales with corresponding mean pulling force measurements from CGMD simulations (Pearson's R = 0.75, Fig. 5B ), which strongly suggests that the pulling forces generated by the translocon-mediated membrane integration of the nascent chain stimulate -1PRF......
Document: Overall, we find the -1PRF efficiency associated with each polyprotein variant roughly scales with corresponding mean pulling force measurements from CGMD simulations (Pearson's R = 0.75, Fig. 5B ), which strongly suggests that the pulling forces generated by the translocon-mediated membrane integration of the nascent chain stimulate -1PRF.
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