Selected article for: "antiviral posture and IFN interferon"
Author: Heaton, Steven M.; Borg, Natalie A.; Dixit, Vishva M.
Title: Ubiquitin in the activation and attenuation of innate antiviral immunity
  • Cord-id: 42d77vxf
  • Document date: 2016_1_11
    • ID: 42d77vxf
    Snippet: Viral infection activates danger signals that are transmitted via the retinoic acid–inducible gene 1–like receptor (RLR), nucleotide-binding oligomerization domain-like receptor (NLR), and Toll-like receptor (TLR) protein signaling cascades. This places host cells in an antiviral posture by up-regulating antiviral cytokines including type-I interferon (IFN-I). Ubiquitin modifications and cross-talk between proteins within these signaling cascades potentiate IFN-I expression, and inversely, a
    Document: Viral infection activates danger signals that are transmitted via the retinoic acid–inducible gene 1–like receptor (RLR), nucleotide-binding oligomerization domain-like receptor (NLR), and Toll-like receptor (TLR) protein signaling cascades. This places host cells in an antiviral posture by up-regulating antiviral cytokines including type-I interferon (IFN-I). Ubiquitin modifications and cross-talk between proteins within these signaling cascades potentiate IFN-I expression, and inversely, a growing number of viruses are found to weaponize the ubiquitin modification system to suppress IFN-I. Here we review how host- and virus-directed ubiquitin modification of proteins in the RLR, NLR, and TLR antiviral signaling cascades modulate IFN-I expression.

    Search related documents:
    Co phrase search for related documents
    • acceptor site and lysine residue: 1
    • acceptor site and lysosomal degradation: 1
    • accessory protein and acid inducible: 1
    • accessory protein and acid inducible gene: 1
    • accessory protein and activate rig: 1
    • accessory protein and activation pathway: 1, 2, 3, 4, 5, 6
    • accessory protein and acute respiratory syndrome sars cov coronavirus: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35
    • accessory protein and lysosomal degradation: 1, 2
    • acid inducible and activate rig: 1, 2, 3, 4
    • acid inducible and activate transcription factor: 1
    • acid inducible and activation cluster: 1
    • acid inducible and activation mechanism: 1
    • acid inducible and activation pathway: 1, 2, 3, 4, 5, 6
    • acid inducible and acute respiratory syndrome sars cov coronavirus: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12
    • acid inducible and adaptive immune response: 1, 2, 3, 4, 5
    • acid inducible and adaptor protein: 1, 2, 3, 4, 5, 6, 7, 8
    • acid inducible and lysine residue: 1