Risk of symptomatic severe acute respiratory syndrome coronavirus 2 infection not associated with influenza vaccination in the 2019–2020 season

King, Jennifer P.; McLean, Huong Q.; Belongia, Edward A.

The association of influenza vaccine and severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection was assessed by test‐negative design using data collected for a study of outpatient COVID‐19‐like illness with onset dates from June to September 2020. Multivariable logistic regression models examined the association between receipt of 2019–2020 influenza vaccine and PCR‐confirmed SARS‐CoV‐2 with adjustment for potential confounders. Receipt of influenza vaccine during the 2019–2020 influenza season was not associated with increased odds of SARS‐CoV‐2 infection in adults (aOR 0.83, 95% CI 0.63 to 1.10) or children (aOR 0.92, 95% CI 0.47 to 1.80).