Selected article for: "average number and infection reproductive number"
Author: Corey M Peak; Lauren M Childs; Yonatan H Grad; Caroline O Buckee
Title: Containing Emerging Epidemics: a Quantitative Comparison of Quarantine and Symptom Monitoring
  • Document date: 2016_8_31
    • ID: 2j4z5rp8_8
    Snippet: The success of these approaches is not simply a reflection of the efficiency of their implementation but crucially depend on the biology and natural history of the pathogen in question. Previous theoretical work by Fraser, et al. (17) summarized these dynamics into a measure of the proportion of infections by asymptomatic infection ( ) and the basic reproductive number ( ! ), defined as the average number of infections generated by an infectious .....
    Document: The success of these approaches is not simply a reflection of the efficiency of their implementation but crucially depend on the biology and natural history of the pathogen in question. Previous theoretical work by Fraser, et al. (17) summarized these dynamics into a measure of the proportion of infections by asymptomatic infection ( ) and the basic reproductive number ( ! ), defined as the average number of infections generated by an infectious individual in a fully susceptible population. Subsequent work has explored the interaction between disease characteristics (e.g., super-spreading (18) ) and the performance of interventions (e.g., travel screening (19) ), but the recent Ebola epidemic demonstrated that at least two large questions remain (7) . Firstly, what is the role of symptom monitoring as an alternative to quarantine, and secondly, how does this choice depend on the characteristics of the disease, the setting, and their interactions?

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