Author: Menon, Rajasree; Otto, Edgar A.; Sealfon, Rachel; Nair, Viji; Wong, Aaron K.; Theesfeld, Chandra L.; Chen, Xi; Wang, Yuan; Boppana, Avinash S.; Luo, Jinghui; Yang, Yingbao; Kasson, Peter M.; Schaub, Jennifer A.; Berthier, Celine C.; Eddy, Sean; Lienczewski, Chrysta C.; Godfrey, Bradley; Dagenais, Susan L.; Sohaney, Ryann; Hartman, John; Fermin, Damian; Subramanian, Lalita; Looker, Helen C.; Harder, Jennifer L.; Mariani, Laura H.; Hodgin, Jeffrey B.; Sexton, Jonathan Z.; Wobus, Christiane E.; Naik, Abhijit S.; Nelson, Robert G.; Troyanskaya, Olga G.; Kretzler, Matthias
Title: SARS-CoV-2 receptor networks in diabetic and COVID-19 associated kidney disease Cord-id: 1jnm1hex Document date: 2020_10_8
ID: 1jnm1hex
Snippet: COVID-19 morbidity and mortality are increased in patients with diabetes and kidney disease via unknown mechanisms. SARS-CoV-2 uses angiotensin-converting enzyme 2 (ACE2) for entry into host cells. Since ACE2 is a susceptibility factor for infection, we investigated how diabetic kidney disease and medications alter ACE2 receptor expression in kidneys. Single cell RNA profiling of healthy living donor and kidney biopsies from patients with diabetic kidney disease revealed ACE2 expression primaril
Document: COVID-19 morbidity and mortality are increased in patients with diabetes and kidney disease via unknown mechanisms. SARS-CoV-2 uses angiotensin-converting enzyme 2 (ACE2) for entry into host cells. Since ACE2 is a susceptibility factor for infection, we investigated how diabetic kidney disease and medications alter ACE2 receptor expression in kidneys. Single cell RNA profiling of healthy living donor and kidney biopsies from patients with diabetic kidney disease revealed ACE2 expression primarily in proximal tubular epithelial cells. This cell specific localization was confirmed by in situ hybridization. ACE2 expression levels were unaltered by exposures to renin angiotensin aldosterone system inhibitors in diabetic kidney disease. Bayesian integrative analysis of a large compendium of public-omics datasets identified molecular network modules induced in ACE2-expressing proximal tubular epithelial cells in diabetic kidney disease (searchable at hb.flatironinstitute.org/covid-kidney) that were linked to viral entry, immune activation, endomembrane reorganization, and RNA processing. The diabetic kidney disease ACE2-positive proximal tubular epithelial cell module overlapped with expression patterns seen in SARS-CoV-2 infected cells. Similar cellular programs were seen in ACE2-positive proximal tubular epithelial cells obtained from urine samples of 13hospitalized patients with COVID-19, suggesting a consistent ACE2-coregulated proximal tubular epithelial cell expression program that may interact with the SARS-CoV-2 infection processes. Thus SARS-CoV-2 receptor networks can seed further research into risk stratification and therapeutic strategies for COVID-19 related kidney damage.
Search related documents:
Co phrase search for related documents- ace angiotensin and additional receptor: 1
- ace angiotensin and macrophage activation: 1, 2
- ace angiotensin convert enzyme and acute respiratory syndrome: 1
- acid activate and acute respiratory syndrome: 1, 2
- acr albumin and acute respiratory syndrome: 1
- acr albumin creatinine and acute respiratory syndrome: 1
- acr albumin creatinine ratio and acute respiratory syndrome: 1
- acute respiratory syndrome and additional receptor: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11
- acute respiratory syndrome and living donor: 1, 2, 3, 4, 5, 6, 7, 8, 9
- acute respiratory syndrome and lower airway: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20
- acute respiratory syndrome and lower airway upper: 1, 2, 3, 4, 5, 6
- acute respiratory syndrome and lower airway upper tissue: 1
- acute respiratory syndrome and macrophage activation: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- live donor and living donor: 1, 2
Co phrase search for related documents, hyperlinks ordered by date