Author: Lamers, Mart M.; Beumer, Joep; van der Vaart, Jelte; Knoops, Kèvin; Puschhof, Jens; Breugem, Tim I.; Ravelli, Raimond B.G.; van Schayck, J. Paul; Mykytyn, Anna Z.; Duimel, Hans Q.; van Donselaar, Elly; Riesebosch, Samra; Kuijpers, Helma J.H.; Schipper, Debby; van de Wetering, Willine J.; de Graaf, Miranda; Koopmans, Marion; Cuppen, Edwin; Peters, Peter J.; Haagmans, Bart L.; Clevers, Hans
Title: SARS-CoV-2 Productively Infects Human Gut Enterocytes Cord-id: 8rho4rim Document date: 2020_4_25
ID: 8rho4rim
Snippet: COVID-19, caused by SARS-CoV-2, is an influenza-like disease with a respiratory route of transmission, yet clinical evidence suggests that the intestine may present another viral target organ. Indeed, the SARS-CoV-2 receptor angiotensin converting enzyme 2 (ACE2) is highly expressed on differentiated enterocytes. In human small intestinal organoids, enterocytes were readily infected by SARS-CoV and SARS-CoV-2 as demonstrated by confocal- and electron-microscopy. Consequently, significant titers
Document: COVID-19, caused by SARS-CoV-2, is an influenza-like disease with a respiratory route of transmission, yet clinical evidence suggests that the intestine may present another viral target organ. Indeed, the SARS-CoV-2 receptor angiotensin converting enzyme 2 (ACE2) is highly expressed on differentiated enterocytes. In human small intestinal organoids, enterocytes were readily infected by SARS-CoV and SARS-CoV-2 as demonstrated by confocal- and electron-microscopy. Consequently, significant titers of infectious viral particles were measured. mRNA expression analysis revealed strong induction of a generic viral response program. We conclude that intestinal epithelium supports SARS-CoV-2 replication. One Sentence Summary SARS-CoV-2 infection of enterocytes in human small intestinal organoids
Search related documents:
Co phrase search for related documents, hyperlinks ordered by date