Author: Yifei Lang; Wentao Li; Zeshi Li; Danielle Koerhuis; Arthur C.S. van den Burg; Erik Rozemuller; Berend-Jan Bosch; Frank J.M. van Kuppeveld; Geert-Jan P.H. Boons; Eric G. Huizinga; Hilde M. van der Schaar; Raoul J. de Groot
Title: Coronavirus hemagglutinin-esterase and spike proteins co-evolve for functional balance and optimal virion avidity Document date: 2020_4_5
ID: 0c7tf0np_9
Snippet: Virus cloning by endpoint dilution yielded, in three out of five isolates, S1 A -Thr 83 Asn variants with the 266 newly introduced N-glycosylation site in HE intact (HE-Thr 114 Asn). Furthermore, a single S1 A -Thr 83 Ile 267 variant was isolated, but this virus in addition had the N-glycosylation site in HE destroyed (HE-.....
Document: Virus cloning by endpoint dilution yielded, in three out of five isolates, S1 A -Thr 83 Asn variants with the 266 newly introduced N-glycosylation site in HE intact (HE-Thr 114 Asn). Furthermore, a single S1 A -Thr 83 Ile 267 variant was isolated, but this virus in addition had the N-glycosylation site in HE destroyed (HE-
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