Author: Collin D. Heer; Daniel J. Sanderson; Yousef M.O. Alhammad; Mark S. Schmidt; Samuel A.J. Trammell; Stanley Perlman; Michael S. Cohen; Anthony R. Fehr; Charles Brenner
Title: Coronavirus Infection and PARP Expression Dysregulate the NAD Metabolome: A Potentially Actionable Component of Innate Immunity Document date: 2020_4_18
ID: 033phqmd_16
Snippet: Finally, though ferrets are susceptible to infection by SARS-CoV-2, they do not progress to the serious disease seen in people (Shi et al., 2020) . We therefore examined the NAD gene set in RNAseq data from the lung of a person who died of COVID-19 (Blanco-Melo et al., 2020) . Though lacking the replicates and the synchrony of the ferret RNAseq data and, with the caveat that tissue from a deceased patient is less likely to produce the highest qua.....
Document: Finally, though ferrets are susceptible to infection by SARS-CoV-2, they do not progress to the serious disease seen in people (Shi et al., 2020) . We therefore examined the NAD gene set in RNAseq data from the lung of a person who died of COVID-19 (Blanco-Melo et al., 2020) . Though lacking the replicates and the synchrony of the ferret RNAseq data and, with the caveat that tissue from a deceased patient is less likely to produce the highest quality RNA, the human data were informative.
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