Selected article for: "care admission and intensive care admission require"
Author: Costela-Ruiz, Víctor J.; Illescas-Montes, Rebeca; Puerta-Puerta, Jose M.; Ruiz, Concepción; Melguizo-Rodríguez, Lucia
Title: SARS-CoV-2 infection: the role of cytokines in COVID-19 disease
  • Cord-id: 8u685f45
  • Document date: 2020_6_2
    • ID: 8u685f45
    Snippet: COVID-19 disease, caused by infection with SARS-CoV-2, is related to a series of physiopathological mechanisms that mobilize a wide variety of biomolecules, mainly immunological in nature. In the most severe cases, the prognosis can be markedly worsened by the hyperproduction of mainly proinflammatory cytokines, such as IL-1, IL-6, IL-12, IFN-γ, and TNF-α, preferentially targeting lung tissue. This study reviews published data on alterations in the expression of different cytokines in patients
    Document: COVID-19 disease, caused by infection with SARS-CoV-2, is related to a series of physiopathological mechanisms that mobilize a wide variety of biomolecules, mainly immunological in nature. In the most severe cases, the prognosis can be markedly worsened by the hyperproduction of mainly proinflammatory cytokines, such as IL-1, IL-6, IL-12, IFN-γ, and TNF-α, preferentially targeting lung tissue. This study reviews published data on alterations in the expression of different cytokines in patients with COVID-19 who require admission to an intensive care unit. Data on the implication of cytokines in this disease and their effect on outcomes will support the design of more effective approaches to the management of COVID-19.

    Search related documents:
    Co phrase search for related documents
    • abnormal level and acute phase: 1
    • abnormal level and acute respiratory syndrome: 1, 2, 3, 4, 5, 6, 7, 8, 9
    • abnormal level and adaptive immunity: 1
    • abnormal level and liver dysfunction: 1, 2
    • activation proliferation and acute ards respiratory distress syndrome: 1, 2
    • activation proliferation and acute phase: 1, 2
    • activation proliferation and acute respiratory syndrome: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11
    • activation proliferation and adaptive immunity: 1, 2, 3, 4, 5
    • activation proliferation and liver dysfunction: 1, 2
    • active form and acute ards respiratory distress syndrome: 1
    • active form and acute respiratory syndrome: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
    • active form and adaptive immunity: 1, 2
    • active form and adenosine nucleotide: 1
    • activity inhibition and acute ards respiratory distress syndrome: 1, 2, 3, 4
    • activity inhibition and acute phase: 1, 2
    • activity inhibition and acute respiratory syndrome: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
    • activity inhibition and adaptive immunity: 1
    • activity inhibition and adenosine nucleotide: 1
    • activity inhibition and liver dysfunction: 1