Author: Wenbin Ji; Yibo Luo; Ejaz Ahmad; Song-Tao Liu
Title: Coordination between discrete Mitotic Arrest Deficient 1 (MAD1) domains is required for efficient mitotic checkpoint signaling Document date: 2017_11_1
ID: i4yquw4k_4
Snippet: Here we report our results targeting the above two questions. While our manuscript was prepared, two reports were published indicating MPS1 phosphorylating MAD1 to enhance MAD2 O-C conversion and the MCC assembly (29, 30) . Our results support the importance of MAD1 Thr716 phosphorylation, but we have also uncovered other protein-protein interactions among MAD1, MAD2 and MPS1 and their phosphorylation dependent regulation. Our work highlights the.....
Document: Here we report our results targeting the above two questions. While our manuscript was prepared, two reports were published indicating MPS1 phosphorylating MAD1 to enhance MAD2 O-C conversion and the MCC assembly (29, 30) . Our results support the importance of MAD1 Thr716 phosphorylation, but we have also uncovered other protein-protein interactions among MAD1, MAD2 and MPS1 and their phosphorylation dependent regulation. Our work highlights the coordination of different MAD1 domains in efficient mitotic checkpoint signaling and provides further mechanistic insights into the O-C conversion reaction.
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