Author: Frediansyah, Andri; Nainu, Firzan; Dhama, Kuldeep; Mudatsir, Mudatsir; Harapan, Harapan
Title: Remdesivir and its antiviral activity against COVID-19: A systematic review Cord-id: 4eejzpmn Document date: 2020_8_7
ID: 4eejzpmn
Snippet: BACKGROUND: To summarize the antiviral activities of remdesivir against SARS-CoV-2, the causative agent of COVID-19. METHODS: Available publications were systematically explored on some databases and gray literature was examined. Publications were discussed narratively. RESULTS: Remdesivir inhibits SARS-CoV-2 replication, reduces viral load, and exerts protective effects in SARS-CoV-2 infected animals. Remdesivir also reduces the pathological process, alleviates mild symptoms, and improves pulmo
Document: BACKGROUND: To summarize the antiviral activities of remdesivir against SARS-CoV-2, the causative agent of COVID-19. METHODS: Available publications were systematically explored on some databases and gray literature was examined. Publications were discussed narratively. RESULTS: Remdesivir inhibits SARS-CoV-2 replication, reduces viral load, and exerts protective effects in SARS-CoV-2 infected animals. Remdesivir also reduces the pathological process, alleviates mild symptoms, and improves pulmonary lesions in SARS-CoV-2-infecetd animals. Although remdesivir has been used as a compassionate drug for treating COVID-19 patients, it has only moderate efficacy. CONCLUSION: Although remdesivir has shown potent antiviral activities, more efficacy assessments are urgently warranted in clinical trials.
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