Selected article for: "expression level and gene expression level"

Author: Lecarpentier, Yves; Vallée, Alexandre
Title: The key role of the level of ACE2 gene expression in SARS-CoV-2 infection
  • Cord-id: 4sfg9iwd
  • Document date: 2021_6_11
  • ID: 4sfg9iwd
    Snippet: SARS-CoV-2 more readily affects the elderly, especially as they present co-morbidities. In the COVID-19 pathogeny, ACE2 appears to be the key cell receptor for SARS-CoV-2 to infect humans. The level of ACE2 gene expression influences the susceptibility of contracting SARS-CoV-2. In circumstances in which the ACE2 level is low, the incidence of Covid-19 seems to be fewer. Two clinical patterns illustrate this observation, i. e., in infants and in Alzheimer's disease (AD). Very young children and
    Document: SARS-CoV-2 more readily affects the elderly, especially as they present co-morbidities. In the COVID-19 pathogeny, ACE2 appears to be the key cell receptor for SARS-CoV-2 to infect humans. The level of ACE2 gene expression influences the susceptibility of contracting SARS-CoV-2. In circumstances in which the ACE2 level is low, the incidence of Covid-19 seems to be fewer. Two clinical patterns illustrate this observation, i. e., in infants and in Alzheimer's disease (AD). Very young children and AD patients get little COVID-19, in part probably due to decreased expression of ACE2. The determination of the nasal level of ACE2 gene expression could provide a useful scale to predict the susceptibility to contract the SARS-CoV-2 infection.

    Search related documents:
    Co phrase search for related documents
    • ace1 angiotensin and acute respiratory syndrome: 1, 2, 3, 4, 5, 6, 7
    • ace1 angiotensin ii and acute respiratory syndrome: 1, 2, 3, 4
    • acute respiratory syndrome and ad animal model: 1