Author: Du, Jian; Luo, Junqiu; Yu, Jie; Mao, Xiangbing; Luo, Yuheng; Zheng, Ping; He, Jun; Yu, Bing; Chen, Daiwen
Title: Manipulation of Intestinal Antiviral Innate Immunity and Immune Evasion Strategies of Porcine Epidemic Diarrhea Virus Cord-id: 4jlc8r53 Document date: 2019_11_3
ID: 4jlc8r53
Snippet: Porcine epidemic diarrhea virus (PEDV) infection causes watery diarrhea, dehydration, and high mortality in neonatal pigs, due to its clinical pathogenesis of the intestinal mucosal barrier dysfunction. The host's innate immune system is the first line of defence upon virus invasion of the small intestinal epithelial cells. In turn, the virus has evolved to modulate the host's innate immunity during infection, resulting in pathogen virulence, survival, and the establishment of successful infecti
Document: Porcine epidemic diarrhea virus (PEDV) infection causes watery diarrhea, dehydration, and high mortality in neonatal pigs, due to its clinical pathogenesis of the intestinal mucosal barrier dysfunction. The host's innate immune system is the first line of defence upon virus invasion of the small intestinal epithelial cells. In turn, the virus has evolved to modulate the host's innate immunity during infection, resulting in pathogen virulence, survival, and the establishment of successful infection. In this review, we gather current knowledge concerning the interplay between PEDV and components of host innate immunity, focusing on the role of cytokines and interferons in intestinal antiviral innate immunity, and the mechanisms underlying the immune evasion strategies of PEDV invasion. Finally, we provide some perspectives on the potential prevention and treatment for PEDV infection.
Search related documents:
Co phrase search for related documents- acid inducible and adaptive innate: 1, 2
- acid inducible and adaptive innate immune response: 1
- acid inducible gene and adapter protein: 1, 2, 3
- acid inducible gene and adaptive innate: 1, 2
- acid inducible gene and adaptive innate immune response: 1
- acid produce and adaptive innate: 1
- activator jak signal transducer and adaptive innate: 1
- activator jak signal transducer and adaptive innate immune response: 1
Co phrase search for related documents, hyperlinks ordered by date