Author: Collin D. Heer; Daniel J. Sanderson; Yousef M.O. Alhammad; Mark S. Schmidt; Samuel A.J. Trammell; Stanley Perlman; Michael S. Cohen; Anthony R. Fehr; Charles Brenner
Title: Coronavirus Infection and PARP Expression Dysregulate the NAD Metabolome: A Potentially Actionable Component of Innate Immunity Document date: 2020_4_18
ID: 033phqmd_26
Snippet: Our data demonstrate the PARP transcriptional induction program is conserved between MHV and SARS-CoV-2 in vitro and in vivo. Further, NAD + and NADP + , the two key hydride accepting coenzymes required for fuel oxidation, the pentose phosphate pathway and-in reduced forms-oxidative phosphorylation and biosynthetic programs have cellular levels that are highly sensitive to CoV infection......
Document: Our data demonstrate the PARP transcriptional induction program is conserved between MHV and SARS-CoV-2 in vitro and in vivo. Further, NAD + and NADP + , the two key hydride accepting coenzymes required for fuel oxidation, the pentose phosphate pathway and-in reduced forms-oxidative phosphorylation and biosynthetic programs have cellular levels that are highly sensitive to CoV infection.
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