Author: Lyn, Rodney K.; Singaravelu, Ragunath; Kargman, Stacia; O'Hara, Shifawn; Chan, Helen; Oballa, Renata; Huang, Zheng; Jones, Daniel M.; Ridsdale, Andrew; Russell, Rodney S.; Partridge, Anthony W.; Pezacki, John Paul
Title: Stearoyl-CoA desaturase inhibition blocks formation of hepatitis C virus-induced specialized membranes Cord-id: 33y74q1k Document date: 2014_4_1
ID: 33y74q1k
Snippet: Hepatitis C virus (HCV) replication is dependent on the formation of specialized membrane structures; however, the host factor requirements for the formation of these HCV complexes remain unclear. Herein, we demonstrate that inhibition of stearoyl-CoA desaturase 1 (SCD-1) halts the biosynthesis of unsaturated fatty acids, such as oleic acid, and negatively modulates HCV replication. Unsaturated fatty acids play key roles in membrane curvature and fluidity. Mechanistically, we demonstrate that SC
Document: Hepatitis C virus (HCV) replication is dependent on the formation of specialized membrane structures; however, the host factor requirements for the formation of these HCV complexes remain unclear. Herein, we demonstrate that inhibition of stearoyl-CoA desaturase 1 (SCD-1) halts the biosynthesis of unsaturated fatty acids, such as oleic acid, and negatively modulates HCV replication. Unsaturated fatty acids play key roles in membrane curvature and fluidity. Mechanistically, we demonstrate that SCD-1 inhibition disrupts the integrity of membranous HCV replication complexes and renders HCV RNA susceptible to nuclease-mediated degradation. Our work establishes a novel function for unsaturated fatty acids in HCV replication.
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