Convalescent Plasma to Treat COVID-19: Chinese Strategy and Experiences

Shiyao Pei; Xi Yuan; Zhimin Zhimin Zhang; Run Run Yao; Yubin Xie; Minxue Minxue Shen; Bijuan Bijuan Li; Xiang Chen; Mingzhu Yin

is the (which was not peer-reviewed) The copyright holder for this preprint . https://doi.org/10.1101/2020.04.07.20056440 doi: medRxiv preprint the patient had improved significantly and the discharge criteria were met on 26th day. We can learn from this case that convalescent plasma treatment can quickly turn the viral nucleic acid test negative and significantly reduced symptoms. The second case was a patient whose nucleic acid test was consistently positive with moderate symptoms, after treatment on 27 th day, the viral nucleic acid test turned negative four days later. Therefore, in order to save medical resources and reduce the transmission of infection, it is advisable to use convalescent plasma treatment on patients with long-term (more than 4 weeks) positive nucleic acid test of novel coronavirus. In the third case, the plasma donor was a 51-year-old woman with a history of pregnancy (supplementary table 2 Additionally, viral load after convalescent plasma treatment was significantly lower on days 3, 5, and 7 after intensive care unit admission 8 .