Selected article for: "catalytic core and mitotic checkpoint"
Author: Wenbin Ji; Yibo Luo; Ejaz Ahmad; Song-Tao Liu
Title: Coordination between discrete Mitotic Arrest Deficient 1 (MAD1) domains is required for efficient mitotic checkpoint signaling
  • Document date: 2017_11_1
    • ID: i4yquw4k_28
    Snippet: Although much of MAD1 has been usually simplified as rather stiff coiled coils, the known structures of MAD1 MIM and MAD1 CTD and careful analyses of MAD1 NTD showed that multiple MAD1 segments may adopt alternative structures or remain disordered (11, 33) (Fig. 1, Fig. S1 ). It is likely that "liganded" C-MAD2 binding to the MIM region of MAD1 still constitutes the catalytic core and represents the stably MAD1-associated MAD2 in cells (Fig. 1e ).....
    Document: Although much of MAD1 has been usually simplified as rather stiff coiled coils, the known structures of MAD1 MIM and MAD1 CTD and careful analyses of MAD1 NTD showed that multiple MAD1 segments may adopt alternative structures or remain disordered (11, 33) (Fig. 1, Fig. S1 ). It is likely that "liganded" C-MAD2 binding to the MIM region of MAD1 still constitutes the catalytic core and represents the stably MAD1-associated MAD2 in cells (Fig. 1e ), but earlier work by others have already lent strong support to possible MAD1-CTD involvement in the mitotic checkpoint responses (12) (13) (14) (15) (16) (17) (18) 29, 30) . At least part of the MAD1-NTD (1-485 residues) contributes to MAD1 nuclear pore or kinetochore localization and interaction with other proteins including Ndc80, Plk1, Nek2A, Tpr, Cep57 and CENP-E (20-23,33,45-49). The regions spanning (400-500) or (420-485) could possibly impact on the mitotic checkpoint (14, 29) . Nevertheless, the possibility that MAD1-NTD and -CTD directly impacts on MAD2 O-C conversion was not thoroughly studied until this work.

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