Author: Zhou, Ting; Su, Tina Tianjiao; Mudianto, Tenny; Wang, Jun
Title: Immune asynchrony in COVID-19 pathogenesis and potential immunotherapies Cord-id: 2eipg6oa Document date: 2020_9_10
ID: 2eipg6oa
Snippet: The outbreak of coronavirus disease 2019 (COVID-19) is an unprecedented global health crisis. Tissue and peripheral blood analysis indicate profound, aberrant myeloid cell activation, cytokine storm, and lymphopenia, with unknown immunopathological mechanisms. Spatiotemporal control of the quality and quantity of the antiviral immune responses involves synchronized cellular and molecular cascades and cross-talk between innate and adaptive immunity. Dysregulated responses in immunity, such as at
Document: The outbreak of coronavirus disease 2019 (COVID-19) is an unprecedented global health crisis. Tissue and peripheral blood analysis indicate profound, aberrant myeloid cell activation, cytokine storm, and lymphopenia, with unknown immunopathological mechanisms. Spatiotemporal control of the quality and quantity of the antiviral immune responses involves synchronized cellular and molecular cascades and cross-talk between innate and adaptive immunity. Dysregulated responses in immunity, such as at the stages of immune sensing, alarming, polarization, and resolution, may contribute to disease pathology. Herein, we approach SARS-CoV-2 through an immunomodulatory lens, discussing possible mechanisms of the asynchronized antiviral immune response and proposing potential therapeutic strategies to correct the dysregulation.
Search related documents:
Co phrase search for related documents- aberrant expression and acute respiratory: 1, 2, 3, 4, 5
- aberrant expression and acute respiratory syndrome coronavirus: 1, 2
- aberrant expression and adaptive immunity: 1
- aberrant hyperinflammation and acute respiratory: 1
- aberrant hyperinflammation and acute respiratory syndrome coronavirus: 1
- activation induce and acute lung injury: 1, 2
- activation induce and acute respiratory: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15
- activation induce and acute respiratory syndrome coronavirus: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10
- activation induce and adaptive immune response: 1, 2, 3, 4
- activation induce and adaptive immunity: 1, 2, 3, 4, 5, 6, 7
- activation induce and adaptive immunity innate immunity: 1
- activation recruitment and acute lung injury: 1, 2, 3, 4, 5, 6, 7, 8, 9
- activation recruitment and acute respiratory: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23
- activation recruitment and acute respiratory syndrome coronavirus: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10
- activation recruitment and adaptive immune response: 1, 2, 3, 4
- activation recruitment and adaptive immune system: 1, 2, 3, 4, 5, 6
- activation recruitment and adaptive immunity: 1, 2, 3, 4, 5
- acute lung injury and adaptive immunity: 1, 2, 3, 4, 5, 6
- acute lung injury and adaptive immunity innate immunity: 1
Co phrase search for related documents, hyperlinks ordered by date