Selected article for: "cell activation and immune response"

Author: Zhou, Ting; Su, Tina Tianjiao; Mudianto, Tenny; Wang, Jun
Title: Immune asynchrony in COVID-19 pathogenesis and potential immunotherapies
  • Cord-id: 2eipg6oa
  • Document date: 2020_9_10
  • ID: 2eipg6oa
    Snippet: The outbreak of coronavirus disease 2019 (COVID-19) is an unprecedented global health crisis. Tissue and peripheral blood analysis indicate profound, aberrant myeloid cell activation, cytokine storm, and lymphopenia, with unknown immunopathological mechanisms. Spatiotemporal control of the quality and quantity of the antiviral immune responses involves synchronized cellular and molecular cascades and cross-talk between innate and adaptive immunity. Dysregulated responses in immunity, such as at
    Document: The outbreak of coronavirus disease 2019 (COVID-19) is an unprecedented global health crisis. Tissue and peripheral blood analysis indicate profound, aberrant myeloid cell activation, cytokine storm, and lymphopenia, with unknown immunopathological mechanisms. Spatiotemporal control of the quality and quantity of the antiviral immune responses involves synchronized cellular and molecular cascades and cross-talk between innate and adaptive immunity. Dysregulated responses in immunity, such as at the stages of immune sensing, alarming, polarization, and resolution, may contribute to disease pathology. Herein, we approach SARS-CoV-2 through an immunomodulatory lens, discussing possible mechanisms of the asynchronized antiviral immune response and proposing potential therapeutic strategies to correct the dysregulation.

    Search related documents:
    Co phrase search for related documents
    • aberrant expression and acute respiratory: 1, 2, 3, 4, 5
    • aberrant expression and acute respiratory syndrome coronavirus: 1, 2
    • aberrant expression and adaptive immunity: 1
    • aberrant expression and adaptive innate: 1, 2, 3, 4
    • aberrant expression and adaptive innate immune cell: 1
    • aberrant expression and lung epithelial cell: 1
    • aberrant expression and lung inflammation: 1
    • aberrant expression and lung injury: 1, 2, 3, 4
    • aberrant hyperinflammation and acute respiratory: 1
    • aberrant hyperinflammation and acute respiratory syndrome coronavirus: 1