Selected article for: "dsrna bind and immune response"

Author: Wilusz, Jeremy E.
Title: Circle the Wagons: Circular RNAs Control Innate Immunity
  • Cord-id: 7yp7km05
  • Document date: 2019_5_2
  • ID: 7yp7km05
    Snippet: Circular RNAs are generated at low levels from many protein-coding genes. Liu et al. now reveal that many of these transcripts bind and inhibit the double-stranded RNA (dsRNA)-dependent kinase PKR. Upon viral infection, circular RNAs are globally degraded to release PKR, which becomes activated to aid in the immune response.
    Document: Circular RNAs are generated at low levels from many protein-coding genes. Liu et al. now reveal that many of these transcripts bind and inhibit the double-stranded RNA (dsRNA)-dependent kinase PKR. Upon viral infection, circular RNAs are globally degraded to release PKR, which becomes activated to aid in the immune response.

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