Author: Meng Yuan; Nicholas C. Wu; Xueyong Zhu; Chang-Chun D. Lee; Ray T. Y. So; Huibin Lv; Chris K. P. Mok; Ian A. Wilson
Title: A highly conserved cryptic epitope in the receptor-binding domains of SARS-CoV-2 and SARS-CoV Document date: 2020_3_14
ID: f03ka7bd_3
Snippet: can bind to the RBD of SARS-CoV-2 (5). This finding provides an opportunity to uncover 51 a cross-reactive epitope. 52 53 CR3022 was previously isolated from a convalescent SARS patient and is encoded by 54 germline genes IGHV5-51, IGHD3-10, IGHJ6 (heavy chain), and IGKV4-1, IGKJ2 (light 55 chain) (4). Based on IgBlast analysis (6), the IGHV of CR3022 is 3.1% somatically 56 mutated at the nucleotide sequence level, which results in eight amino-ac.....
Document: can bind to the RBD of SARS-CoV-2 (5). This finding provides an opportunity to uncover 51 a cross-reactive epitope. 52 53 CR3022 was previously isolated from a convalescent SARS patient and is encoded by 54 germline genes IGHV5-51, IGHD3-10, IGHJ6 (heavy chain), and IGKV4-1, IGKJ2 (light 55 chain) (4). Based on IgBlast analysis (6), the IGHV of CR3022 is 3.1% somatically 56 mutated at the nucleotide sequence level, which results in eight amino-acid changes 57 from the germline sequence, whereas IGKV of CR3022 is 1.3% somatically mutated 58 resulting in three amino-acid changes from the germline sequence (fig. S1). We 59 therefore determined the crystal structure of CR3022 with the SARS-CoV-2 RBD at 3.1 60 Ã… resolution (table S1 and fig.S2 , A and B) (7). CR3022 uses both heavy and light 61 chains (Fig. 1B) , and all six complementarity-determining region (CDR) loops (Fig. 1C)
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