Author: Meng Yuan; Nicholas C. Wu; Xueyong Zhu; Chang-Chun D. Lee; Ray T. Y. So; Huibin Lv; Chris K. P. Mok; Ian A. Wilson
Title: A highly conserved cryptic epitope in the receptor-binding domains of SARS-CoV-2 and SARS-CoV Document date: 2020_3_14
ID: f03ka7bd_9
Snippet: Out of 28 residues in the epitope (defined as residues buried by CR3022), 24 (86%) are 68 conserved between SARS-CoV-2 and SARS-CoV (Fig. 1D ). This high sequence 69 conservation explains the cross-reactivity of CR3022. Nonetheless, despite having a 70 high conservation in the epitope residues, CR3022 Fab binds to SARS-CoV RBD (K d = 1 71 nM) with a much higher affinity than to SARS-CoV-2 RBD (K d = 115 nM) (Table 1.....
Document: Out of 28 residues in the epitope (defined as residues buried by CR3022), 24 (86%) are 68 conserved between SARS-CoV-2 and SARS-CoV (Fig. 1D ). This high sequence 69 conservation explains the cross-reactivity of CR3022. Nonetheless, despite having a 70 high conservation in the epitope residues, CR3022 Fab binds to SARS-CoV RBD (K d = 1 71 nM) with a much higher affinity than to SARS-CoV-2 RBD (K d = 115 nM) (Table 1
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