Author: Collin D. Heer; Daniel J. Sanderson; Yousef M.O. Alhammad; Mark S. Schmidt; Samuel A.J. Trammell; Stanley Perlman; Michael S. Cohen; Anthony R. Fehr; Charles Brenner
Title: Coronavirus Infection and PARP Expression Dysregulate the NAD Metabolome: A Potentially Actionable Component of Innate Immunity Document date: 2020_4_18
ID: 033phqmd_14
Snippet: was also easy to discern other significant alterations to the NAD gene set. The data indicate that transcription of NMRK1 and concentrative nucleoside transporter CNT3 go up, suggesting increased capacity for conversion of nicotinamide riboside to NAD + and NADP + (Bieganowski & Brenner, 2004) . Notably, in mouse models of damaged brain and heart, upregulation of NMRK gene expression is associated with therapeutic efficacy of NR (Vaur et al., 201.....
Document: was also easy to discern other significant alterations to the NAD gene set. The data indicate that transcription of NMRK1 and concentrative nucleoside transporter CNT3 go up, suggesting increased capacity for conversion of nicotinamide riboside to NAD + and NADP + (Bieganowski & Brenner, 2004) . Notably, in mouse models of damaged brain and heart, upregulation of NMRK gene expression is associated with therapeutic efficacy of NR (Vaur et al., 2017; Diguet et al., 2018) . Additionally, the ferret data show strongly depressed NNMT expression-by decreasing NAM methylation, this gene expression change could promote NAM salvage (Neelakantan et al., 2019) and the efficiency of NAD-boosting by NR (Trammell, Schmidt, et al., 2016) , representing a homeostatic attempt of virally infected cells to maintain their NAD metabolome (Brenner, 2014) .
Search related documents:
Co phrase search for related documents- damage brain and heart damage brain: 1, 2, 3, 4, 5, 6, 7
- damage brain and mouse model: 1, 2, 3, 4, 5, 6, 7, 8
- gene expression and increase capacity: 1, 2, 3, 4, 5, 6
- gene expression and mouse model: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- gene expression and NAD gene: 1, 2, 3, 4
- gene expression and nad metabolome: 1
- gene expression and NAM salvage: 1
- gene expression and nicotinamide riboside: 1, 2
- gene expression and NMRK gene expression: 1
- gene expression change and increase capacity: 1
- NAD gene and NAM salvage: 1
- NAD gene and nicotinamide riboside: 1
- nad metabolome and NAM salvage: 1
- NAM salvage and nicotinamide riboside: 1
Co phrase search for related documents, hyperlinks ordered by date