Selected article for: "autocrine paracrine manner and paracrine manner"
Author: Collin D. Heer; Daniel J. Sanderson; Yousef M.O. Alhammad; Mark S. Schmidt; Samuel A.J. Trammell; Stanley Perlman; Michael S. Cohen; Anthony R. Fehr; Charles Brenner
Title: Coronavirus Infection and PARP Expression Dysregulate the NAD Metabolome: A Potentially Actionable Component of Innate Immunity
  • Document date: 2020_4_18
    • ID: 033phqmd_2
    Snippet: We and others showed that CoVs elicit an IFN response in naïve cells. In this process, IFN proteins are secreted by infected cells to engage IFN receptors and, in an autocrine and paracrine manner, induce expression of a set of IFN-stimulated genes (ISGs). The collective activities of ISGs reorient cellular metabolism toward infection control (Channappanavar et al., 2019) . Among the ISGs are several members of the poly(ADP-ribose) polymerase (P.....
    Document: We and others showed that CoVs elicit an IFN response in naïve cells. In this process, IFN proteins are secreted by infected cells to engage IFN receptors and, in an autocrine and paracrine manner, induce expression of a set of IFN-stimulated genes (ISGs). The collective activities of ISGs reorient cellular metabolism toward infection control (Channappanavar et al., 2019) . Among the ISGs are several members of the poly(ADP-ribose) polymerase (PARP) superfamily (Alhammad & Fehr, 2020; Fehr et al., 2020) .

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