Author: Nyayanit, Dimpal A.; Sarkale, Prasad; Shete-Aich, Anita; Kumar, Abhinendra; Patil, Savita; Majumdar, Triparna; Baradkar, Shreekant; Gawande, Pranita; Mohandas, Sreelekshmy; Yadav, Pragya D
Title: Possible role of accessory proteins in the viral replication for the 20I/501Y.V1 (B.1.1.7) SARS-CoV-2 variant Cord-id: 283llw7c Document date: 2021_5_3
ID: 283llw7c
Snippet: The study investigates the replication cycle and transcriptional pattern of the B.1.1.7 variant. It was observed that the B.1.1.7 variant required a longer maturation time. The transcriptional response demonstrated higher expression of ORF6 and ORF8 compared to nucleocapsid transcript till the eclipse period which might influence higher viral replication. The number of infectious viruses titer is higher in the B.1.1.7, despite a lesser copy number than B.1, indicating higher infectivity.
Document: The study investigates the replication cycle and transcriptional pattern of the B.1.1.7 variant. It was observed that the B.1.1.7 variant required a longer maturation time. The transcriptional response demonstrated higher expression of ORF6 and ORF8 compared to nucleocapsid transcript till the eclipse period which might influence higher viral replication. The number of infectious viruses titer is higher in the B.1.1.7, despite a lesser copy number than B.1, indicating higher infectivity.
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