Author: Courtney R. Sullivan; Catharine A. Mielnik; Sinead M. O’Donovan; Adam J. Funk; Eduard Bentea; Erica A.K. DePasquale; Zhexing Wen; Vahram Haroutunian; Pavel Katsel; Amy J. Ramsey; Jarek Meller; Robert E. McCullumsmith
Title: Connectivity analyses of bioenergetic changes in schizophrenia: Identification of novel treatments Document date: 2018_6_5
ID: ltb6l5xz_27
Snippet: We performed Enrichr analyses on our panels of clustered downregulated genes from our iLINCS clustering analysis. Top cell signaling pathways include pathways relevant to immune/inflammatory responses and cell cycle regulation ( Figure S11 ). The top 5 hits in our GO cellular components analysis for our panels of clustered downregulated genes implicated mitochondrial function ( Figure S12 ), while the top hits for GO molecular function included s.....
Document: We performed Enrichr analyses on our panels of clustered downregulated genes from our iLINCS clustering analysis. Top cell signaling pathways include pathways relevant to immune/inflammatory responses and cell cycle regulation ( Figure S11 ). The top 5 hits in our GO cellular components analysis for our panels of clustered downregulated genes implicated mitochondrial function ( Figure S12 ), while the top hits for GO molecular function included several RNA polymerase promotors/activators ( Figure S13 ). Our protein-protein interactions analysis ( Figure S14 ) yielded multiple hits for chromatin remodeling proteins (PCNA, HDAC1, HDAC2, CREBBP). We also found hits for proteins involved in immunity/cell cycle regulation (NFKB2, CSNK2A1, MYC), and ubiquitination (BRCA1).
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