Author: Courtney R. Sullivan; Catharine A. Mielnik; Sinead M. O’Donovan; Adam J. Funk; Eduard Bentea; Erica A.K. DePasquale; Zhexing Wen; Vahram Haroutunian; Pavel Katsel; Amy J. Ramsey; Jarek Meller; Robert E. McCullumsmith
Title: Connectivity analyses of bioenergetic changes in schizophrenia: Identification of novel treatments Document date: 2018_6_5
ID: ltb6l5xz_44
Snippet: Notably, knockdown of PFKL impairs glycolysis and promotes metabolism via the pentose phosphate pathway (69) . Decreases in PFKL or PFKM expression in schizophrenia could affect normal enzyme activity, resulting in either decreased glycolytic breakdown of glucose or an inability to upregulate glycolysis when energy demand is high. Interestingly, the human PFKL gene is located on chromosome 21 and abnormal expression of PFKL is associated with Dow.....
Document: Notably, knockdown of PFKL impairs glycolysis and promotes metabolism via the pentose phosphate pathway (69) . Decreases in PFKL or PFKM expression in schizophrenia could affect normal enzyme activity, resulting in either decreased glycolytic breakdown of glucose or an inability to upregulate glycolysis when energy demand is high. Interestingly, the human PFKL gene is located on chromosome 21 and abnormal expression of PFKL is associated with Down's syndrome (70) . Additionally, we previously reported decreased PFK activity in the DLPFC of schizophrenia subjects (18) .
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