Broad-Spectrum Antiviral Peptides and Polymers.

Kuroki, Agnès; Tay, Joyce; Lee, Guan Huei; Yang, Yi Yan

As the human cost of the pandemic caused by the SARS-CoV-2 is still being witnessed worldwide, the development of broad-spectrum antiviral agents against emerging and re-emerging viruses is seen as a necessity to hamper the spread of infections. Various targets during the viral life-cycle can be considered to inhibit viral infection, from viral attachment to viral fusion or replication. Macromolecules represent a particularly attractive class of therapeutics due to their multivalency and versatility. Although several antiviral macromolecules hold great promise in clinical applications, the emergence of resistance after prolonged exposure urges the need for improved solutions. In the present article, we review the recent advancement in the discovery of antiviral peptides and polymers with diverse structural features and antiviral mechanisms. Future perspectives, such as the development of virucidal peptides/polymers and their coatings against SARS-CoV-2 infection, standardization of antiviral testing protocols, and use of artificial intelligence or machine learning as a tool to accelerate the discovery of antiviral macromolecules, are discussed. This article is protected by copyright. All rights reserved.