Tailoring Nutrition Therapy amid the COVID-19 pandemic: Does it work?

Chada, Radha Reddy; Chidrawar, Sachin; Siddiqua, Ayesha; Medanki, Rajiv; Omer, Syeda Amena; Nagalla, Balakrishna

Background The COVID-19 pandemic has been a challenge for nutrition monitoring and delivery. This study evaluates clinical and nutritional characteristics of patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and investigates the relationship between nutrition delivery and clinical outcomes. Methods Prospective observational study of adults admitted for >24hrs to a tertiary-care hospital during a period of 2months. Data was collected on disease severity, energy, protein delivery and adequacy, use of mechanical ventilation (MV), hospital length of stay (LOS). Multivariate logistic regression models were used to determine the associations with mortality as the primary outcome. Results 1083 patients: 69% male (n=747), 31% females (n=336), mean age 58.2±12.8 with 26.6±4.32 BMI were analysed. 1021 patients survived and 62 deaths occurred, with 183 and 900 patients in the ICU and ward, respectively. Inadequate calorie and protein delivery had significantly higher mortality than those with adequate provision (p < 0.001) among the ICU patients. In bivariate logistic regression analysis, adequacy of energy and protein, disease severity, comorbidities ≥3, NRS score ≥3 and prone ventilation correlates with mortality (p < 0.001). In multivariate logistic regression analysis of the ICU patients, energy inadequacy (OR:3.6, 95%CI:1.25-10.2) and prone ventilation (OR:11.0, 95%CI:3.8-31.9) were significantly (p<0.05) associated with mortality after adjusting for disease severity, comorbidities and MV days. Conclusion Most patients infected with SARS-CoV-2 are at nutrition risk that can impact outcome. Our data suggest that addressing nutritional adequacy can be one of the measures to reduce hospital LOS, and mortality among nutritionally risk patients.