Author: Meng Yuan; Nicholas C. Wu; Xueyong Zhu; Chang-Chun D. Lee; Ray T. Y. So; Huibin Lv; Chris K. P. Mok; Ian A. Wilson
Title: A highly conserved cryptic epitope in the receptor-binding domains of SARS-CoV-2 and SARS-CoV Document date: 2020_3_14
ID: f03ka7bd_11
Snippet: Mass spectrometry analysis has shown that a complex glycan is indeed present at this 79 N-glycosylation site in . An N-glycan at N370 would fit into a groove 80 formed between heavy and light chains ( fig. S4C ), which could increase contact and, 81 hence, binding affinity to CR3022. We then tested whether CR3022 was able to 82 neutralize SARS-CoV-2 and SARS-CoV in an in vitro microneutralization assay (7)......
Document: Mass spectrometry analysis has shown that a complex glycan is indeed present at this 79 N-glycosylation site in . An N-glycan at N370 would fit into a groove 80 formed between heavy and light chains ( fig. S4C ), which could increase contact and, 81 hence, binding affinity to CR3022. We then tested whether CR3022 was able to 82 neutralize SARS-CoV-2 and SARS-CoV in an in vitro microneutralization assay (7).
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