Author: Collin D. Heer; Daniel J. Sanderson; Yousef M.O. Alhammad; Mark S. Schmidt; Samuel A.J. Trammell; Stanley Perlman; Michael S. Cohen; Anthony R. Fehr; Charles Brenner
Title: Coronavirus Infection and PARP Expression Dysregulate the NAD Metabolome: A Potentially Actionable Component of Innate Immunity Document date: 2020_4_18
ID: 033phqmd_29
Snippet: Protein synthesis depends on copious supplies of GTP, whose charge depends on fuel oxidation, while lipid synthesis is linked to the generation of reducing equivalents from the pentose phosphate pathway. Our data indicate that viral infection significantly depresses the NAD metabolome, which is likely to invoke significant stress on cells as CoVs commandeer nucleotides for their use despite lower levels of the critical coenzymes for their synthes.....
Document: Protein synthesis depends on copious supplies of GTP, whose charge depends on fuel oxidation, while lipid synthesis is linked to the generation of reducing equivalents from the pentose phosphate pathway. Our data indicate that viral infection significantly depresses the NAD metabolome, which is likely to invoke significant stress on cells as CoVs commandeer nucleotides for their use despite lower levels of the critical coenzymes for their synthesis.
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