Author: Collin D. Heer; Daniel J. Sanderson; Yousef M.O. Alhammad; Mark S. Schmidt; Samuel A.J. Trammell; Stanley Perlman; Michael S. Cohen; Anthony R. Fehr; Charles Brenner
Title: Coronavirus Infection and PARP Expression Dysregulate the NAD Metabolome: A Potentially Actionable Component of Innate Immunity Document date: 2020_4_18
ID: 033phqmd_6
Snippet: In support of the antiviral roles of IFN-induced MARylating PARP isozymes, PARP12 was shown to promote the degradation of nsp1 and nsp3 in Zika virus infection (L. Li et al., 2018) . PARP12 has also been shown to inhibit a wide variety of RNA viruses, including several alphaviruses, which also contain an nsp3-encoded CARH activities (Atasheva, Akhrymuk, Frolova, & Frolov, 2012; Atasheva, Frolova, & Frolov, 2014) . Further, the nsp10 of SARS-CoV h.....
Document: In support of the antiviral roles of IFN-induced MARylating PARP isozymes, PARP12 was shown to promote the degradation of nsp1 and nsp3 in Zika virus infection (L. Li et al., 2018) . PARP12 has also been shown to inhibit a wide variety of RNA viruses, including several alphaviruses, which also contain an nsp3-encoded CARH activities (Atasheva, Akhrymuk, Frolova, & Frolov, 2012; Atasheva, Frolova, & Frolov, 2014) . Further, the nsp10 of SARS-CoV has been identified as an inhibitor of electron transport at the NADH site of complex I in the mitochondrial electron transport chain (Q. Li et al., 2005) . These observations suggest that key events in the innate immune response to viral infections are played out in the infected cell's NAD metabolome.
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