Selected article for: "BCG vaccination and immune response"
Author: Aaron Miller; Mac Josh Reandelar; Kimberly Fasciglione; Violeta Roumenova; Yan Li; Gonzalo H Otazu
Title: Correlation between universal BCG vaccination policy and reduced morbidity and mortality for COVID-19: an epidemiological study
  • Document date: 2020_3_28
    • ID: 35meen0h_3
    Snippet: Several vaccines including the BCG vaccination have been shown to produce positive "heterologous" or non-specific immune effects leading to improved response against other nonmycobacterial pathogens. For instance, BCG vaccinated mice infected with the vaccinia virus were protected by increased IFN-Y production from CD4+ cells 2 . This phenomenon was named 'trained immunity' and is proposed to be caused by metabolic and epigenetic changes leading .....
    Document: Several vaccines including the BCG vaccination have been shown to produce positive "heterologous" or non-specific immune effects leading to improved response against other nonmycobacterial pathogens. For instance, BCG vaccinated mice infected with the vaccinia virus were protected by increased IFN-Y production from CD4+ cells 2 . This phenomenon was named 'trained immunity' and is proposed to be caused by metabolic and epigenetic changes leading to promotion of genetic regions encoding for pro-inflammatory cytokines 3 . BCG vaccination significantly increases the secretion of pro-inflammatory cytokines, specifically IL-1B, which has been shown to play a vital role in antiviral immunity 4 . Additionally, a study 5 in Guinea-Bissau found that children vaccinated with BCG were observed to have a 50% reduction in overall mortality, which was attributed to the vaccine's effect on reducing respiratory infections and sepsis.

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