Author: Huan Ma; Weihong Zeng; Hongliang He; Dan Zhao; Yunru Yang; Dehua Jiang; Peigen Zhou; Yingjie Qi; Weihuang He; Changcheng Zhao; Ruting Yi; Xiaofang Wang; Bo Wang; Yuanhong Xu; Yun Yang; Arnaud John Kombe Kombe; Chengchao Ding; Jiajia Xie; Yong Gao; Linzhao Cheng; Yajuan Li; Xiaoling Ma; Tengchuan Jin
Title: COVID-19 diagnosis and study of serum SARS-CoV-2 specific IgA, IgM and IgG by a quantitative and sensitive immunoassay Document date: 2020_4_22
ID: 4jeaqqn9_58
Snippet: The copyright holder for this preprint . https://doi.org/10.1101/2020.04.17.20064907 doi: medRxiv preprint IgA is traditionally recognized to play an anti-inflammatory role and prevent tissue damage at mucosal 375 sites. However, recent reports also demonstrated that serum IgA is involved in the formation of immune 376 complexes to amplify inflammatory responses. 38 Serum IgA induced proinflammatory cytokine 377 production by macrophages, monocyt.....
Document: The copyright holder for this preprint . https://doi.org/10.1101/2020.04.17.20064907 doi: medRxiv preprint IgA is traditionally recognized to play an anti-inflammatory role and prevent tissue damage at mucosal 375 sites. However, recent reports also demonstrated that serum IgA is involved in the formation of immune 376 complexes to amplify inflammatory responses. 38 Serum IgA induced proinflammatory cytokine 377 production by macrophages, monocytes and Kupffer cells in non-mucosal tissues including liver, skin 378 and peripheral blood. 39 In this study, we observed that IgA was present in COVID-19 patients' serum, 379 and its levels positively correlated with COVID-19 severity ( figure 3A) . In our cohort, we also observed 380 that IgG levels were associated with worse clinical outcomes (figure 3C), as previously described 10, 21 .
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