Author: Collin D. Heer; Daniel J. Sanderson; Yousef M.O. Alhammad; Mark S. Schmidt; Samuel A.J. Trammell; Stanley Perlman; Michael S. Cohen; Anthony R. Fehr; Charles Brenner
Title: Coronavirus Infection and PARP Expression Dysregulate the NAD Metabolome: A Potentially Actionable Component of Innate Immunity Document date: 2020_4_18
ID: 033phqmd_22
Snippet: The NAD metabolome is not only modulated by gene expression changes, enzyme activity and precursor availability, but also by subcellular localization (Cambronne et al., 2016) . Thus, restoration of total cellular NAD + does not necessarily equate to restoration of specific enzyme activities (Ryu et al., 2018) . To determine whether PARP10 activity is modulated by NAMPT activation or PARP1/PARP2 inhibition, we took advantage of the auto-MARylation.....
Document: The NAD metabolome is not only modulated by gene expression changes, enzyme activity and precursor availability, but also by subcellular localization (Cambronne et al., 2016) . Thus, restoration of total cellular NAD + does not necessarily equate to restoration of specific enzyme activities (Ryu et al., 2018) . To determine whether PARP10 activity is modulated by NAMPT activation or PARP1/PARP2 inhibition, we took advantage of the auto-MARylation activity of PARP10 as a readout of its activity in cells. PARP10 auto-MARylation activity was stimulated by SBI-797812. In contrast, treatment with veliparib did not affect PARP10 auto-MARylation (Figure 4) .
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