Author: Collin D. Heer; Daniel J. Sanderson; Yousef M.O. Alhammad; Mark S. Schmidt; Samuel A.J. Trammell; Stanley Perlman; Michael S. Cohen; Anthony R. Fehr; Charles Brenner
Title: Coronavirus Infection and PARP Expression Dysregulate the NAD Metabolome: A Potentially Actionable Component of Innate Immunity Document date: 2020_4_18
ID: 033phqmd_36
Snippet: Failure of veliparib to stimulate PARP10 auto-MARylation activity despite restoring NAD + levels in this preclinical study can be considered less promising for approach 7, though additional models and molecules should be assessed. It is striking, however, that depressed NAD + In herpes virus infection is attributed to PARP1,2 activation (Grady et al., 2012) and this apparently is not the case for CoVs......
Document: Failure of veliparib to stimulate PARP10 auto-MARylation activity despite restoring NAD + levels in this preclinical study can be considered less promising for approach 7, though additional models and molecules should be assessed. It is striking, however, that depressed NAD + In herpes virus infection is attributed to PARP1,2 activation (Grady et al., 2012) and this apparently is not the case for CoVs.
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