Selected article for: "ifn induction and type ifn induction"
Author: Zhao, Wei
Title: Negative regulation of TBK1-mediated antiviral immunity
  • Cord-id: 8hvwkswf
  • Document date: 2013_3_18
    • ID: 8hvwkswf
    Snippet: TANK-binding kinase 1 (TBK1) plays pivotal roles in antiviral innate immunity. TBK1 mediates the activation of interferon regulatory factor (IRF) 3, leading to the induction of type I IFNs (IFN-α/β) following viral infections. TBK1 must be tightly regulated to effectively control viral infections and maintain immune homeostasis. TBK1 activity can be regulated in a variety of ways, such as phosphorylation, ubiquitination, kinase activity modulation and prevention of functional TBK1-containing c
    Document: TANK-binding kinase 1 (TBK1) plays pivotal roles in antiviral innate immunity. TBK1 mediates the activation of interferon regulatory factor (IRF) 3, leading to the induction of type I IFNs (IFN-α/β) following viral infections. TBK1 must be tightly regulated to effectively control viral infections and maintain immune homeostasis. TBK1 activity can be regulated in a variety of ways, such as phosphorylation, ubiquitination, kinase activity modulation and prevention of functional TBK1-containing complexes formation. Furthermore, multiple viruses have evolved elaborate strategies to circumvent IFN responses by targeting TBK1. Here we provide an overview of TBK1 in antiviral immunity and recent developments on the regulation of TBK1 activity.

    Search related documents:
    Co phrase search for related documents
    • acidinducible gene retinoic and adaptor protein: 1
    • activation facilitate and acute respiratory syndrome: 1, 2
    • activation loop and acute respiratory syndrome: 1, 2, 3, 4, 5
    • activity balance and acute respiratory syndrome: 1, 2, 3, 4, 5, 6
    • activity independent and acute respiratory syndrome: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18
    • activity independent and adaptor protein: 1
    • activity inhibit and acute respiratory syndrome: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
    • activity modulation and acute respiratory syndrome: 1, 2, 3, 4, 5, 6, 7, 8, 9
    • acute respiratory syndrome and adaptor protein: 1, 2, 3, 4, 5
    • acute respiratory syndrome and local concentration: 1