Author: Haley R. Harrington; Matthew H. Zimmer; Laura M. Chamness; Veronica Nash; Wesley D. Penn; Thomas F. Miller; Suchetana Mukhopadhyay; Jonathan P. Schlebach
Title: Cotranslational Folding Stimulates Programmed Ribosomal Frameshifting in the Alphavirus Structural Polyprotein Document date: 2019_10_2
ID: 4ju3x2bf_2
Snippet: -1PRF occurs during synthesis and processing of the nascent alphavirus structural polyprotein at the endoplasmic reticulum (ER) membrane. Following autoproteolytic cleavage of CP in the cytosol, a signal peptide at the N-terminus of the E3 protein directs the nascent polyprotein to the endoplasmic reticulum (ER) lumen where processing of the downstream proteins occurs......
Document: -1PRF occurs during synthesis and processing of the nascent alphavirus structural polyprotein at the endoplasmic reticulum (ER) membrane. Following autoproteolytic cleavage of CP in the cytosol, a signal peptide at the N-terminus of the E3 protein directs the nascent polyprotein to the endoplasmic reticulum (ER) lumen where processing of the downstream proteins occurs.
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