Author: Munblit, Daniel; Bobkova, Polina; Spiridonova, Ekaterina; Shikhaleva, Anastasia; Gamirova, Aysylu; Blyuss, Oleg; Nekliudov, Nikita; Bugaeva, Polina; Andreeva, Margarita; DunnGalvin, Audrey; Comberiati, Pasquale; Apfelbacher, Christian; Genuneit, Jon; Avdeev, Sergey; Kapustina, Valentina; Guekht, Alla; Fomin, Victor; Svistunov, Andrey A.; Timashev, Peter; Subbot, Vladislav S.; Royuk, Valery V.; Drake, Thomas M.; Hanson, Sarah Wulf; Merson, Laura; Carson, Gail; Horby, Peter; Sigfrid, Louise; Scott, Janet T.; Semple, Malcolm G.; Warner, John O.; Vos, Theo; Olliaro, Piero; Glybochko, Petr; Butnaru, Denis
Title: Incidence and risk factors for persistent symptoms in adults previously hospitalized for COVIDâ€19 Cord-id: 2amh20vu Document date: 2021_8_12
ID: 2amh20vu
Snippet: BACKGROUND: The longâ€term sequalae of COVIDâ€19 remain poorly characterized. We assessed persistent symptoms in previously hospitalized patients with COVIDâ€19 and assessed potential risk factors. METHODS: Data were collected from patients discharged from 4 hospitals in Moscow, Russia between 8 April and 10 July 2020. Participants were interviewed via telephone using an ISARIC Longâ€term Followâ€up Study questionnaire. RESULTS: 2,649 of 4755 (56%) discharged patients were successfully eval
Document: BACKGROUND: The longâ€term sequalae of COVIDâ€19 remain poorly characterized. We assessed persistent symptoms in previously hospitalized patients with COVIDâ€19 and assessed potential risk factors. METHODS: Data were collected from patients discharged from 4 hospitals in Moscow, Russia between 8 April and 10 July 2020. Participants were interviewed via telephone using an ISARIC Longâ€term Followâ€up Study questionnaire. RESULTS: 2,649 of 4755 (56%) discharged patients were successfully evaluated, at median 218 (IQR 200, 236) days postâ€discharge. COVIDâ€19 diagnosis was clinical in 1291 and molecular in 1358. Most cases were mild, but 902 (34%) required supplemental oxygen and 68 (2.6%) needed ventilatory support. Median age was 56 years (IQR 46, 66) and 1,353 (51.1%) were women. Persistent symptoms were reported by 1247 (47.1%) participants, with fatigue (21.2%), shortness of breath (14.5%) and forgetfulness (9.1%) the most common symptoms and chronic fatigue (25%) and respiratory (17.2%) the most common symptom categories. Female sex was associated with any persistent symptom category OR 1.83 (95% CI 1.55 to 2.17) with association being strongest for dermatological (3.26, 2.36 to 4.57) symptoms. Asthma and chronic pulmonary disease were not associated with persistent symptoms overall, but asthma was associated with neurological (1.95, 1.25 to 2.98) and mood and behavioural changes (2.02, 1.24 to 3.18), and chronic pulmonary disease was associated with chronic fatigue (1.68, 1.21 to 2.32). CONCLUSIONS: Almost half of adults admitted to hospital due to COVIDâ€19 reported persistent symptoms 6 to 8 months after discharge. Fatigue and respiratory symptoms were most common, and female sex was associated with persistent symptoms.
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